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Home - Products - Chromatin/Epigenetic - Epigenetic Reader Domain - Histone Acetyltransferase Inhibitor II

Histone Acetyltransferase Inhibitor II

CAS No. 932749-62-7

Histone Acetyltransferase Inhibitor II( —— )

Catalog No. M22025 CAS No. 932749-62-7

Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Histone Acetyltransferase Inhibitor II
  • Note
    Research use only, not for human use.
  • Brief Description
    Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells.
  • Description
    Histone Acetyltransferase Inhibitor II is a selective and cell permeable inhibitor of p300 histone acetyltransferase(IC50 : 5 μM).with anti-acetylase activity in mammalian cells. Histone Acetyltransferase Inhibitor II (compound 2c) was the most active inhibitor, also showing high specificity for p300 as compared to other histone acetyltransferases.?Most notably, 2c showed anti-acetylase activity in mammalian cells.
  • In Vitro
    Histone Acetyltransferase Inhibitor II (20-40 μM) decreases the levels of H3 acetylation in HeLa-H2B-EYFP cells.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Chromatin/Epigenetic
  • Target
    Epigenetic Reader Domain
  • Recptor
    p300
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    932749-62-7
  • Formula Weight
    464.15
  • Molecular Formula
    C20H16Br2O3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:30 mg/mL (64.63 mM)
  • SMILES
    C1CC(=CC2=CC(=C(C=C2)O)Br)C(=O)C(=CC3=CC(=C(C=C3)O)Br)C1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Costi R, et al. Cinnamoyl compounds as simple molecules that inhibit p300 histone acetyltransferase. J Med Chem. 2007 Apr 19;50(8):1973-7. Epub 2007 Mar 10.
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